Chiefs
| Position | Player | Injury | Participation |
| C | Rudy Niswanger | Knee | None |
| WR | Mark Bradley | Calf | Limited |
| LB | Donnie Edwards | Knee | Limited |
| CB | Maurice Leggett | Shoulder | Limited |
| CB | Patrick Surtain | Quad | Limited |
| G | Adrian Jones | Ankle | Full |
| LB | Pat Thomas | Hamstring | Full |
Chargers
| Position | Player | Injury | Participation |
| LB | Anthony Waters | Hamstring | None |
| DT | Jamal Williams | Non-injury related | None |
| LB | Marques Harris | Hamstring | Limited |
| S | Clinton Hart | Shoulder | Limited |
| FB | Mike Tolbert | Shoulder | Limited |
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