SAN DIEGO CA - DECEMBER 12: Ryan Mathews #24 of the San Diego Chargers turns from Derrick Johnson #56 of the Kansas City Chiefs during the third quarter in a 31-0 win at Qualcomm Stadium on December 12 2010 in San Diego California. (Photo by Harry How/Getty Images)
So three of those guys are likely out. The KC Star's Adam Teicher made an early guess at the inactives and predicted Brown would be out.
So that's two starters who are more than likely out and three more whose status is up in the air.