It’s not just formational shifts that might occur in the near future, but rather fundamental changes within current offenses. Brown addressed one such change in a recent post for Grantland, subtitled "How modern offenses are rethinking the most fundamental elements of football ‘plays.’"
In that post Brown examined how the 2011 Packers implemented an approach that Oklahoma State had used to great success with Brandon Weeden at quarterback: packaging plays. In short, offensive coordinators are now beginning to give their quarterbacks both a run and a pass play for each snap. Without simplifying it too much, the quarterback essentially inherits the same responsibilities he would on a zone-read — basing his post-snap decision off one particular defensive player (usually a linebacker). Here, rather than opting to hand off or keep the ball, the quarterback must choose between a pass or run, based on what coverage that keyed defender shows.
Thiggy and the Chiefs are prevalent in this article from SI